Background: Central post-stroke pain (CPSP) is a neuropathic pain syndrome associated with somatosensory abnormalities due to central nervous system lesion following a cerebrovascular insult. Post-stroke pain (PSP) refers to a broader range of clinical conditions leading to pain after stroke, but not restricted to CPSP, including other ity of life. Post-stroke pain (PSP) is a common but not take much attention in stroke research; in different studies its prevalence varies from 18.6 to 49% [1]. The criteria most commonly included in CPSP are "Develop-ment of pain with onset at or after the stroke, Pain lo-cated on the stroke-affected side of the body and No Pain is a serious problem after a stroke. Post stroke pain is usually underdiagnosed and poorly understood. Post stroke pain is often recur because the respond partially to the therapy [11,12]. In gen - eral, there are 2 types of post-stroke pain, CPSP which stimulated by central mechanism and post stroke pain which stimulated by peripheral mecha - Pain is one of the most troublesome sequelae of stroke. Some of this post-stroke pain is caused by the brain lesion itself; this is called central post-stroke pain (CPSP). Although the prevalence of CPSP is low (1-8 %), persistent, often treatment-resistant, painful sensations are a major problem for stroke patients. The pathogenesis of CPSP remains unknown, but suggested underlying causes Fig. 2 Forest plot (a) for the prevalence of central post-stroke pain amongst patients with stroke at any location. The asymmetry in the respective funnel plot (b) indicates probable publication bias 3282 Adv Ther (2020) 37:3278-3291. 11% (n = 72) [44] and in the young 6% Pain experienced after a stroke is one of the most challenging consequences following this life-changing event. A syndrome known as central post-stroke pain (CPSP) is a central neuropathic pain condition characterized by pain and sensory abnormalities that manifest in the body parts that correspond to the area of the brain that has been injured Central post-stroke pain develops within 1-2 months after stroke in 40%-80% of patients. Within this period, either central pain cannot be detected or detection is delayed because the pa- tients are not in rehabilitation clinics, do not have an adequate level of cognition to express themselves, or are aphasic. A 28 Control groups 29 CPSP patients were compared to two control groups: i. post-stroke pain that was non-neuropathic in 30 nature (PSP-Non), and ii. stroke patients without chronic pain (No-Pain). These groups were recruited 31 from the cerebrovascular diseases outpatient clinic from the department of Neurology, University of São 32 Paulo. Central post-stroke pain syndrome (CPSP) is a debilitating sequel that can follow thalamic sensory stroke. Less well recognized, CPSP follows lateral medullary stroke and parietal cortical stroke and may develop anywhere along the spinothalamic or trigemino-thalamic pathways. Abstract Central post-stroke pain (CPSP) used to be known as 'thalamic syndrome'. Early post-mortem studies showed that many cases had extrathalamic lesions, and modern imaging methods have confirmed and extended these findings. CPSP affects between 2 and 6% of stroke patients, ie, there is an annual incidence in the UK of between 2000 and 6000. The percent- somatosensory evoked potential in central post stroke pain. J Pain 2008;9:1116 -22 age of pain reduction was larger after real stimulation 4. H